Anti-tumor activity of newcastle disease virus strains (af 2240 and v4-upm) on aom-induced acf in sprague–dawley rats

  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Declaration of views_handler_argument::init() should be compatible with views_handler::init(&$view, $options) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_argument.inc on line 744.
  • strict warning: Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_filter.inc on line 607.
  • strict warning: Declaration of views_handler_filter::options_submit() should be compatible with views_handler::options_submit($form, &$form_state) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_filter.inc on line 607.
  • strict warning: Declaration of views_handler_filter_boolean_operator::value_validate() should be compatible with views_handler_filter::value_validate($form, &$form_state) in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/handlers/views_handler_filter_boolean_operator.inc on line 159.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalijdr.com/sites/all/modules/views/views.module on line 906.
Author: 
Rowa M. Assayaghi, Aied M. Alabsi, Abdul Manaf Ali and Gumballi Swethadri
Abstract: 

Azoxymethane rat model is a well-established, well-appreciated, and widely used model of experimental colon carcinogenesis. Anti-tumor activity of Newcastle disease virus (NDV) strains AF2240 and V4-UPM was evaluated in-vivo to investigate the effect of different doses of NDV on the development of aberrant crypt foci (ACF) in Sprague–Dawley rats initiated with the colon carcinogen azoxymethane (AOM). The total number and crypt multiplicity as well as the degree of dysplasia of ACF were significantly decreased in treated groups with high doses of NDV compared to the groups which treated with low NDV doses. We also investigated the efficacy of the combination of NDV and 5-FU on the development of ACF in rats’ colon. RT-PCR of some colon cancer markers (COX-1and COX-2) and histopathological studies were carried out and had confirmed ACF results which showed significant decreased of ACF numbers.

Download PDF: 

CHIEF EDITOR

  

           Prof. Dr. Bilal BİLGİN

Call for Papers - 2017

    submit your paper now

   Vol. 07, Issue 03, March 2017

CURRENT ISSUE

 

Article Tracking

IMPACT FACTOR 2016

          4.753

Get your Certificate

Copyright © 2016 International Journal Development Research. All Rights Reserved.