Antimicrobial investigation of different medications against nosocomial infections causing Staphylococcus aureus

Since it was first described in the 1990s, Methicillin-Resistant Staphylococcus aureus infection among people with no contact with a hospital setting or with no traditional risk factors has spread worldwide and is now an important epidemiological and public health problem. This study aims to emphasize the current importance of this emergent pathogen in our area. In the present study we have analyzed the impact of modified MRSA screening of carriers and patients on epidemiological situation of MRSA during 2010-2013 in Gwalior region of Central India. All S. aureus isolates included in this study were identified with the use of standard microbiological methods. Susceptibility testing of all S. aureus isolates was done with use of the CLSI broth micro-dilution method and interpreted on the basis of CLSI criteria. The proportion of MRSA to all S. aureus isolates was found to be 57.6%. The plasmid carrying drug resistant gene was also reported in the biochemically identified S. aureus isolates. Independent of the prevention and intervention strategy in the hospitals the different MRSA incidence seems to be due to regional epidemic settings. Understanding the epidemiology of Staphylococcus aureus (reservoirs, transmission pathways, and risk factors) can result in excellent control of this major pathogen in hospitals and community. This finding is indicative of the spread of drug resistant S. aureus within health care networks, suggesting that control efforts aimed at interrupting the spread within and between health care institutions may not only be feasible but ultimately successful and should therefore be strongly encouraged.