Assessment of liver functions tests in grand Multiparity in second trimester pregnant ladies

Background: Changes in value of certain serum liver function tests occur during normal pregnancy and an understanding of these physiological changes is necessary for the management of liver diseases.
Objective: To compare the levels of liver function tests in grand multiparas with nulliparas [control] and primiparas.
 Materials: A cross-sectional study was performed in 100 non-pregnant ladies as control group, 100 primiparity pregnant women, and 100 grand multiparity pregnant women. All pregnant women were between 20th - 30th weeks gestation.
Methods: Aspartate transaminase [AST], alanine transaminase [ALT], alkaline phosphatase [ALP], direct bilirubin [D.BIL] and total bilirubin [T.BIL] concentrations, as well as total protein and albumin were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure.
Results: When compared to control group, the levels of AST, ALT, ALP, albumin and total protein revealed significant reduction in multiparity women, while direct bilirubin was increase significantly. On the other hand, in comparison to primiparity, levels of ALT, ALP, and total bilirubin showed significant reduction in multiparity women, while direct bilirubin was increase significantly.
Conclusion: The results suggest that grand multiparity increased the risk of pregnancy-related complication secondary to liver dysfunction.