Association of abo blood groups with serum total cholesterol and triglyceride in healthy volunteers

So far, no studies have been performed in Jordan to look at association of ABO blood groups with high serum cholesterol and triglyceride. These biochemical markers are strongly implicated in the development of cardiovascular diseases. Recently, it has been identified ABO as focus for thrombosis, myocardial infarction and cardiovascular biomarkers. The relationships between ABO blood groups total cholesterol and triglyceride concentrations have been evaluated in many studied but the results differ. One hundred ninety four healthy subjects were participated in the study. There were 39% male and 61% female participants with age range of 21 to 55 years. Blood groups, total serum cholesterol and triglyceride levels were determined. Data were analyzed with SPSS program and by applying ANOVA test. The p-value less than 0.05 was considered statistically significant. ANOVA test results showed that there was an association between ABO blood groups total cholesterol and triglyceride levels were negatively associated with A blood group (p<0.05), higher in individual with A-antigen than in subject without this antigen, but no significant association was noted between total cholesterol and blood group was negatively associated with triglyceride levels (p= 0.320). The results in present preliminary study revealed that in our population there was a negative association between ABO blood group A and total cholesterol and there was also a negative association between ABO blood groups, B and AB groups with triglyceride levels. Further studies are necessary to confirm the mechanisms by which ABO blood type or closely linked genetic variants may influence cardiovascular disease in our population, may be only family history of CAD had significant relation with ABO.