Ccr5 co-receptor expression on circulating cd4+lymphocytes in hiv-1 patients on haart at moi teaching and referral hospital, eldoret-Kenya
International Journal of Development Research
Ccr5 co-receptor expression on circulating cd4+lymphocytes in hiv-1 patients on haart at moi teaching and referral hospital, eldoret-Kenya
Received 29th August 2017; Received in revised form 24th September, 2017; Accepted 09th October, 2017; Published online 30th November, 2017
Copyright ©2017, Simiyu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
HIV-1 continues to be a major public health problem globally and particularly in Sub-Saharan Africa. The expression of CCR5 co-receptors and its influence on HIV-1 entry into host cells and tissues has been studied mostly in developed countries outside Africa. The impact of HAART on the expression of CCR5 co-receptor on host cells is little studied in Sub-Saharan Africa. This study focused on expression of CCR5 co-receptor on circulating CD4+ T cells in HIV-1 patients on HAART. A cross-sectional study design of 48 adult HIV-1 patients on HAART and an equal number of HAART naïve were recruited. Blood samples were assayed for CD4+ T cells and CCR5 co-receptor by FACS Calibur® while viral loads were quantified by COBAS® Amplicor version 2. The median expression (%) of CCR5 co-receptors on CD4+T were1.32 and 0.80 in patients on HAART and HAART naïve respectively, p=0.003. The median in the viral loads (copies/ml) were 111.5 and 39301 in patients on HAART and the HAART naïve respectively, p=0.001.This study concluded that HAART up-regulates CCR5 co-receptor expression in HIV-1 infected participants compared to HIV-1 infected but HAART naïve counterparts.
