To perform the comparative study between Curcuma longa Nanosuspension and suspension. Poor bioavailability is one of the leading causes of compound failure in preclinical and clinical development as reported in literatures Gao (2012). Bioavailability of a compound depends on its solubility or dissolution rate Vyas et al. (2013). Dissolution may be the rate determining step for bioavailability and medicinal value, therefore, efforts to increase dissolution rate for water insoluble drug is often needed Sun et al. (2012). It has been observed that Nanosuspension formulated for curcuminoids which is hydrophobic in nature enhanced the solubility as well as dissolution of curcuminoids as compared to suspension Chavhan and Sawant (2011). Nanosuspension of curcumin exhibited better dissolution as well as bioavailability as compared to suspension.
Prof. Dr. Bilal BİLGİN