Correlation between basket and paddle dissolution test methods by drug release in solid dosage forms from Nizatidine and Ramipril
International Journal of Development Research
Correlation between basket and paddle dissolution test methods by drug release in solid dosage forms from Nizatidine and Ramipril
Received 12th September, 2017; Received in revised form 07th October, 2017; Accepted 14th November, 2017; Published online 30th December, 2017
Dr. Sambasiva Rao, and Hareesh Reddy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Dissolutions studies used both paddle and basket methods to carry to cumulative percent of drug release. In both apparatus which one performs good drug releasing characteristics and simplicity? Pharmaceutical companies strive to ensure that the drugs they product are manufactured in a way that they get absorbed at a rate that will ensure optimum effectiveness of the drug in the body. The rotating speed of the shaft and temperature of the liquid in the vessel is precisely controlled to stomach. The time taken to fully dissolve to sample is then recorded for the scientific analysis. The paddle dissolution method and basket dissolution methods however have unique differences in the way they are carried out. In both methods same conditions are maintained but difference only basket instead of paddle in the equipment. The cumulative perentage of controlled drug release in both methods was very slight difference. Above research studies they are confirm to use in Nizatidine and Ramipril matrix tablets, the percentage of drug release was very slight difference and correlated
