Diagnostic value of serum cancer antigen 125 in ovarian cancer patients

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International Journal of Development Research

Volume: 
8
Article ID: 
11984
7 pages
Research Article

Diagnostic value of serum cancer antigen 125 in ovarian cancer patients

Rimaz Alhag Gurashi Moawia E. Hummeida and F. G. Abdelaziz

Received 05th October, 2017; Received in revised form 26th November, 2017; Accepted 20th December, 2017; Published online 31st January, 2018

Copyright © 2018, Rimaz Alhag Gurashi and Moawia E. Hummeida. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract: 

Amongst all gynecological cancers, ovarian cancer is the most lethal malignancy worldwide, aggressive local invasion and the lack of sensitive early screening methods, poses the most difficult in early diagnosis, furthermore, its high mortality rate has made it one of the most investigated fields in gynecological oncology during this year in USA. The aim of the study is to assess the level of serum biomarker cancer antigen (CA-125), among ovarian cancer women at Khartoum State - Sudan. and compare the findings of the cancer antigen (CA-125)serum concentration with the control group, and correlate with study variables. Then estimate the predictive values of this marker. (CA-125) testing were performed to all serum samples to determine the concentrations of cancer antigen CA-125automated immunoassay system (TOSOH BIOCIENCE).for quantitative determination of Cancer Antigen 125 (OVCA125).By the end of this study, concludes that epithelial ovarian cancer is the most common followed by germ cell tumors. Serum level of cancer antigen (CA-125) biomarker within the reference range in the control group. In contrast, increasing serum level in the ovarian cancer patients, A general agreement that a combination of multiple biomarkers may increase diagnostic sensitivity and specificity over use of individual markers (CA125).

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