Effect of hyperlipidemic diet on wistar rats hyperlipidemic diet on wistar rats

Obesity is defined as a chronic inflammatory disease characterized by accumulation of fat in the body. The increase in body weight through the consumption of saturated fats can trigger the onset of chronic non-communicable diseases, metabolic syndrome and insulin resistance. Thus, this study aimed to evaluate the feeding behavior and the physiological changes in fatty tissues of rats after hyperlipidemic diet. 8 Wistar rats were divided into two groups: Control Group, with a standard diet and Intervention Group, with a hyperlipidemic diet. During 16 weeks of treatment, the food intake and weight gain of the animals were evaluated. After this period, the white retroperitoneal, epididymal, mesenteric, perirenal and omental adipose tissues were weighed for posterior quantitative analysis. Regarding food intake, the Control Group showed significantly greater difference when compared to the Intervention Group. However, there was no statistical difference in the average weight gain of each group during the study. In the Intervention Group, the hyperlipidemic diet promoted increase in the retroperitoneal, epididymal, mesenteric and perirenal adipose tissues. There was no difference in relation to the omental adipose tissue. It was concluded that the hyperlipidemic diet was able to induce obesity and may lead to the onset of chronic non-communicable diseases.