Effect of polymer concentrationon drug release in the formulation controlled release tablets of glipizideusing various polymers
International Journal of Development Research
Effect of polymer concentrationon drug release in the formulation controlled release tablets of glipizideusing various polymers
Received 11th January, 2023; Received in revised form 26th January, 2023; Accepted 08th February, 2023; Published online 28th February, 2023
Copyright©2023, Bruno Cardoso Menezes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The objective of the present study was to develop Controlled release tablets of Glipizide using different polymers. The tablets were prepared with different ratios of Eudragit RSPO, Sodium alginate and Sodium CMC by direct compression technique. The solubility study of the Glipizide was conducted to select a suitable dissolution media for in vitro drug release studies. FTIR study revealed no considerable changes in IR peak of Glipizide and Hence no interaction between drug and the excipients. In vitro release from the formulation F5 was found to be 99.31 %. From all the results of dissolution data fitted to various drug release Kinetic equations. It was observed that highest correlation was found for Higuchi release kinetics mechanism.
