Effects of metformin, glimepiride, sitagliptin and their combinations on blood glucose levels in streptozotocin induced diabetes mellitus in albino rats

According to “The International Diabetes Federation”, the number of people living with diabetes worldwide is expected to rise from 366 million in 2011 to 552 million by 2030. This equates to approximately three new cases every ten seconds or almost ten million cases per year. The International Diabetes Federation (IDF) reports a projected prevalence of 70 million patients in India by the year 2025, and the World Health Organization (WHO) estimates that India will have 80 million cases of diabetes by 2030. This places India second only to China in terms of number of people living with diabetes. Prevalence of Diabetes is increasing day-by-day in our country. The average cost of treating a diabetic in India has been estimated at 575 US Dollars or Rs.28750 annually in terms of direct costs, while, indirect costs like lost work-time, would account for another 100 US Dollars or Rs.5000 annually the greatest number of people with diabetes is between 40-59 years of age.