Effects of statins on endothelial function in coronary artery disease

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International Journal of Development Research

Effects of statins on endothelial function in coronary artery disease

Abstract: 

Cardiovascular Diseases (CVD) are currently the leading cause of death globally for both men and women accounting for 21.9 per cent of total deaths and is projected to increase to 26.3 per cent by 2030. Statins are the treatment of choice for the primary and secondary prevention of cardiovascular disease and in the management of hypercholesterolemia because of their proven efficacy and safety profile. Evidences showed their effectiveness in reduction of cholesterol synthesis and number of pleiotropic effects, which may be cholesterol dependent and cholesterol independent. The present review focus on the origin, properties and effects of statins on endothelial function (non lipid action of statins) through the increase of endogenous production of NO in different pathways.

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