Ethanolic extract leaves of eugenia dysenterica dc improves the lipid profile in mice with diabetes induced by streptozotocin

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International Journal of Development Research

Volume: 
08
Article ID: 
11703
8 pages
Research Article

Ethanolic extract leaves of eugenia dysenterica dc improves the lipid profile in mice with diabetes induced by streptozotocin

Lidiani Figueiredo Santana, Bruna Larissa Spontoni do Espirito Santo, Sandramara Sasso, Diana Figueiredo de Santana Aquino, Claudia Andréa Lima Cardoso, Arnildo Pott, Fabíola Lacerda Pires Soares and Karine de Cássia Freitas

Abstract: 

The ethanolic extract of the leaves of E. dysenterica (EEC) was evaluated for its antioxidant activity and was then tested for toxicity administered to both the control group and the treated group (2000 mg/kg EEC). For an experimental model of diabetes, animals were divided into experimental groups: a negative control treated with saline, a group treated with streptozotocin (STZ) combined with saline, a group treated with STZ combined with metformin and the others treated with EEC at doses of 25, 50 and 100 mg/kg of body weight (21 days). The antioxidant activity by the β-carotene/linoleic acid method and by the DPPH free radical method was 113±1 and 107±2 μg/ml, respectively. Total flavonoids and total phenols were 147±1 and 204±5 mg/g, respectively. In the acute toxicity test, EEC did not cause alterations. Regarding the DM model and the treatment with the extract, glycemia was not reduced, but there was an increase in HDL cholesterol (p<0.05) and a decrease in LDL cholesterol (p<0.001) in the group receiving 25 mg/extract/kg. The VLDL and triglycerides levels were significantly reduced at all doses (p<0.001). We concluded that EEC did not present hypoglycemic activity, but there was a significant beneficial effect on serum lipids.

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