Fibromyalgia Syndrome among Patients with Hypothyroidism in mosul

Objective: To study the relationship between fibromyalgia syndrome and hypothyroidism patients in Mosul city. Patients and methods: A case –control study design was adopted .The two stages classification process proposed by 1990 American College of Rheumatology multicenter criteria committee of FMS was applied as an objective assessment of hypothyroidism patient and control group about full history, complete clinical examination and thyroid hormone analysis. Stage I: A pain questionnaire was given a sample of 124 (74 female and 50 male) consecutive patients with hypothyroidism mean age 24.8 years (range 16-60 years) who were attending thyroid clinic in Oncology and Nuclear Hospital in Mosul. Stage II: All patients with chronic wide spread pain were examined by same examiner for 18 binder points. Another 124 healthy individuals matched for age and sex were examined as controls. Results: Chronic wide spread pain was present in 42 of 124 (33.9%) hypothyroidism patients compared to only 29 (23.4%) individual in the control group (P=0.0001). Fibromyalgia syndrome was present in 22 of 124 (17.7%) hypothyroidism patients are compared to only 5 (4%) individuals in the control group( OR = 5.13 ,P=0.001). Female patients with hypothyroidism have high percentage of chronic wide spread pain and fibromyalgia syndrome compared to male patients in the study group. There were positive correlation between fibromyalgia syndrome and hypothyroidism patients with regard to duration of hypothyroidism of more than five years (P=0.0008) but no significant relation with dose of Levothyroxine, age and Body Mass Index Conclusion: Chronic wide spread pain and fibromyalgia syndrome are positively associated with hypothyroidism. fibromyalgia syndrome is more common in female who had disease duration ≥ 5 and within middle age. No role of Levothyroxin in the present study.