Gastric cancer: biological markers as prognostic factor

International Journal of Development Research

Article ID: 
8 pages
Research Article

Gastric cancer: biological markers as prognostic factor

Layane Barreto Costa, Lucas Solon Dias de Farias, Noele Gurgel d’Ávila, Irami Araújo-Neto, Francisco Irochima Pinheiro, Eduardo Pereira de Azevedo, Amália Cinthia Meneses do Rêgo, Fausto Pierdoná Guzen and Irami Araújo-Filho


The present study had as objective to conduct a literature review on the gastric adenocarcinoma and the influence of biological markers as prognostic factors and mortality, contributing to future forms of treatment. A review of the literature on the subject, including the latest research on the topic, published in the last two years. The studies selected were divided into 11 categories: a) E-cadherin in patients with gastric cancer; b) expression of Her-2 gene; c) Integrin αvβ6 and Metalloproteinase 9; d) Expression of MACC1 and KAI1 on metastasis and prognosis; e) Value of CIP2A expression in advanced gastric cancer; f) Antigen MAGE-A and NY-ESO-1; g) CA 74-2, CA 125 and radical resection; h) AEG-1 Oncogene as prognostic biomarker; I) associated with Macrophages tumors (TAM); j) cancer resectable Score; k) Natural therapy. It was observed that gastric adenocarcinoma is currently the third global cause of death related to cancer. In Brazil, the stomach cancer is a third and fifth place of the cause of death for men and women, respectively. Studies have shown numerous biological markers, such as E-cadherin, TAM, CA 125, Metalloproteinase-9, which had a decisive impact on disease resections, bringing in a positive way the prognosis of the patients. In conclusion, one can say that the identification and determination of biological markers are of extreme importance in the treatment and prognostic evaluation of patients affected by gastric adenocarcinoma.

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