Histopathological and oxidative features in alloxan-induced diabetic rats’ kidneys and the preventive effects of the 3,4-dihydroxy-phenylethanol

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International Journal of Development Research

Histopathological and oxidative features in alloxan-induced diabetic rats’ kidneys and the preventive effects of the 3,4-dihydroxy-phenylethanol

Abstract: 

There is a big relationship between Diabete and renal dysfunctions and lesions. This study was designed to test the antidiabetic and antioxidative activities of 3,4-dihydroxy-phenylethanol in kidneys. Diabetes in Wistar rats was induced by intra- peritoneal injections of alloxan. The kidneys antioxidant parameters; thiobarbituric acid-reactive substances (TBARS), catalase (CAT) and Trolox equivalent antioxidant capacity (TEAC) were examined as well as the histological features. Diabetic rats, which have a clear hyperglycaemia, showed significant kidneys oxidative stress establishment and histological lesions. Four weeks 3,4-dihydroxy-phenylethanol administration at 8 mg/kg b.w, restored significantly the renal oxidant damages and the kidneys lesions. These results prove that the antioxidant olive leaf 3,4-dihydroxy-phenylethanol, via its important antioxidant efficiency, protect kidneys from diabetes complications which are usually associated with nephropathy or renal dysfunctions.

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