Mitochondrial dysfunction is heavily noticed by increasing production of reactive oxygen species (ROS) production that are generated as a byproduct of aerobic respiration and various other metabolic processes. To regulate the level of ROS in the human body calorie restriction (CR) and antioxidant plays a dramatic role in maintaining the metabolism of the body. CR is a non – genetic intervention defined as a reduction in calories intake without malnutrition. CR simply slows down the metabolism of the body as a result less production of ROS occurs and hence prevents from cellular damage. If the generation of free radical exceeds the protective effect of antioxidants and its co- factors then the oxidative damage occurs causing various diseases like cancer, cardiovascular diseases, neurodegenerative diseases and other comorbidities. Antioxidant in lay man term defined as the scavenger of free radical. Therefore, this paper focuses on interrelationship between calorie restriction, antioxidant and mitochondrial metabolism i.e. how calorie restriction and antioxidant play contributing role in decreasing the ROS generation.
Prof. Dr. Bilal BİLGİN