Isoeugenol efficacy against Staphylococcus aureus

Background: Staphylococcus aureus is a Gram-positive bacterium responsible for the development of infections of varying degrees of complexity. In addition, due to resistance phenomena, treatment against this pathogen has become increasingly ineffective, making it necessary to search for new molecules with antibacterial activity. Objective: The present study aims to evaluate isoeugenol antibacterial activity against clinical strains of Staphylococcus aureus through in vitro assays. Methodology: It was held Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), Time-kill curve and checkerboard association of isoeugenol with standard antibiotic (gentamicin). Results: Isoeugenol presented 512 μg/mL MIC, > 4096 μg / mL in the MBC assay and demonstrated non-concentration-dependent bacteriostatic activity. The substance had synergistic and additive results when associated with gentamicin. Conclusion: Isoeugenol is an interesting alternative to be better understood, and further studies are needed to better investigate its mechanism of antibacterial action.