The keratoacanthoma (ka) skin lesions in two zambian men:

Keratoacanthoma (KA) is a low-grade skin tumor that originates in the pilosebaceous glands. Clinically, KA lesions cannot be easily differentiated from a more serious skin cancer similar to Squamous Cell Carcinoma (SCC). (Keratoacanthoma, 2004) The tumor usually begins in the skin's pilosebaceous glands, or hair follicles and grows quickly over the first few weeks but do not spread to other parts of the body. If left alone, the lesions will usually disappear by themselves in 4 to 6 months. This condition usually occurs in older individuals. The precise cause is not known but like squamous cell carcinoma, it seems that ultraviolet light from the sun causes the development of KA (Schwartz, 2004). Sporadic cases have been found co-infected with the Human Papilloma Virus (HPV) (Niebuhr, 2009). It is also believed that other factors may play a part, including heavy exposure to the sun, contact with some chemicals, smoking, suppressed immune system, and minor injuries to the skin. The generalized eruptive keratoacanthoma (also known as "Generalized eruptive keratoacanthoma of Grzybowski") is a cutaneous condition; a variant of keratoacanthomas characterized by hundreds to thousand us of tiny follicular keratotic papules over the entire body. Treatments and cure are not usually successful for many patients with Generalized eruptive keratoacanthoma. Use of emollients and anti-itch medications can ease some symptoms. Improvement or complete resolution of this condition are not usually reached. Many new treatments of Melanoma are also known to increase the rate of Keratoacanthoma, such as the B-Raf inhibitor drugs Vemurafenib and Dabrafenib (Niezgoda et al., 2015). Keywords : Keratoancathoma (KA), SCC (Squamus Cell Carcinoma), Giant (KA), HPV (Human papilloma virus), Aggressive.