Melorheostosis affectedpainfull limb improved with zolodronic acid – Case report of a rare disease

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Author: 
Dr. Saikat Sau
Abstract: 

In 1922 Leri and Joanny, first described Melorheostosis (synonyms: candle bone disease, melting wax syndrome, Leri disease). Actually it’s a metaplacia. Men and women are equally affected, dermatomal distribution, monomelic distribution. Onset is insidious, and most common symptom is pain. Classical radiological appearance of ‘flowing hyperosteosis’ resembling hardened wax that has dripped down the side of a candle. Recent literature shows relation with LEMD 3, encode inner nuclear protine,
Case repot: A 30 years old woman, residing at Tarakeswar, Hooghly, West Bengal, presented with left leg pain with mild swelling and limitation of knee movement. On examination non tender bony heard swelling and restriction of knee movement present. Plain radiographs showed extensive, dense, undulating or irregular cortical hyperostosis, resembling candle wax, extending along the length of bone. Zolidronicacid decrease her pain.
Conclusion: Melorheostosis, rare, benign, insidious, candle wax. Routine laboratory findings usually are normal. The exact cause remain unclear. There is nodefinite treatment available for this disease. Only symptomatic treatment improve the condition of the patients, more fruitful result obtain with zolodronicacid.

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