Multiple Effects Of Intravitreal Aflibercept On Microvascular Regression In Eyes With Diabetic Macular Edema
International Journal of Development Research
Multiple Effects Of Intravitreal Aflibercept On Microvascular Regression In Eyes With Diabetic Macular Edema
Received 11th May, 2019; Received in revised form 06th June, 2019; Accepted 03rd July, 2019 ;Published online 28th August, 2019
Copyright © 2019, Dan Călugăru and Mihai Călugăru. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The authors are commenting on the article entitled “Multiple effects of intravitreal aflibercept on microvascular regression in eyes with diabetic macular edema” published by Sugimoto et al. in Ophthalmology Retina; http:/dx.doi.org/10.1016/j.oret.2019.0600. Published online: June 14, 2019. The authors of this study concluded that the intravitreal injections of aflibercept reduced significantly the mean number of microaneurysms from 49.6 to 24.8 and the mean ischemic index from 55.5% to 28.8% at 3 months after initial treatment. However, the validation, extrapolation, and generalizability of these findings are questionable because 60% of the patients were additionally treated with panretinal photocoagulation during the study period, what affected the final outcomes, making impossible distinction between the effects of aflibercept injections and panretinal photocoagulation.
