Pathway construction of chronic inflammatory demyelinating polyneuropathy (CIPD): a neurodegenerative disease

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Author: 
Shamima Khatoon and Ruchi Yadav
Abstract: 

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a form of peripheral neuropathy, often difficult to diagnose. It’s an auto immune disorder, due to subtle occurrence, this disease is not much studied and mostly people are unaware of symptoms and cause. In this paper protein interaction map has been constructed that shows the relationship of CIDP disease with other neurological diseases and also nature of protein interaction. The proteins responsible for the disease (CIDP) were identified using extensive literature survey, Uni Prot and KEGG databases. Protein interaction map was constructed with the help of different softwares like Cytoscape, Gene MANIA, String, Pathway common and Biocarta. The protein interaction map of CIDP shows the nature of protein interaction such as Physical interaction, Neighbor hood, Co- expression, Pathway, Co-localization etc. This protein interaction map of CIDP and protein relatedness with other neurological disease might serve as a source of information to develop new drug targets and a potential cure or control for the neural disease.

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   Vol. 07, Issue 03, March 2017

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