Gynecological malignancies carry a high mortality among women of all age groups not only in Pakistan but also worldwide. It has diverse pattern of distribution worldwide. According to different studies it has been seen that cervical cancer is one of the leading gynecological malignancy worldwide but various studies from Pakistan showed that ovarian cancer is the top most malignancy As no statistical data regarding gynecological malignancies in Khyber Pakhtunkhaw is available, the purpose of this study was to know the pattern of gynecological malignancies in patients registered at IRNUM (Institute of Radiotherapy and Nuclear Medicine Peshawar). This retrospective study was carried out at IRNUM from 1st Jan 1994 to 31dec 2010.Clinical records of 4331 patients were evaluated. Information regarding age, marital status, parity, histopathological type, surgical record, tumor markers and radiological findings were recorded on specifically designed proforma. 4331 patients of gynecological malignancies constituted 5.69 % of all malignant tumors registered at IRNUM during 1994-2010 and 12.5% of all female malignancies at IRNUM. Ovarian cancer was the most frequent, comprising 42% of all gynecological malignancies. Most frequent histopathology was epithelial ovarian cancers constituted 87% of all ovarian cancers. Cervical cancer is the second most common malignancy in our analysis unlike to other studies in this region which shows it the most frequent. Squamous cell was the most frequent histopathology comprising 88%. The 3rd most common gynecological malignancy was endometrial carcinoma. Adenocarcinoma was the most frequent histopathology comprising 70.9%. Gestational trophoblastic tumors (GTT) were the fourth commonly occurring malignancy contributing 10% of all gynecological malignancies. Vulval and vaginal cancers were least occurring gynecological malignancies 4% and 2% respectively.
Prof. Dr. Bilal BİLGİN