Pharmacological activity of the flavonoid pectolinarin from the leaves of lantana camara (verbenaceae)

The leaves of Lantana camarawere submitted to preliminary phytochemical study obtaining essential oil and methanolic extract. In the analysis of the essential oil (hydrodistillation), they identified cariophilene (7.3%), Germacrene B (37.5%) and Germacrene D (21.7%) as the most relevant of the nine components obtained. The ethyl acetate (EtOAc) revealed from the partition of the ethanolic extract (EtOH) of the Leaves of L. camara was subjected to filtration and column chromatography (CC) resulted in lavone, unheard of in the species. The structure was defined as 1 H and 13 C (1 D and 2 D) by nuclear magnetic resonance (NMR) and mass spectrometry, similar to 5'-O-α-L-rhamminopyranosyl-1'-β-D- glucopyranosyl-4', 6-dimethoxyflavone, pectolinarin. This compound has been subjected to biological tests, larvicide, acetyl cholinesterase, antioxidant and cytotoxicity. The compound isolated at 600 ppm, caused low mortality. A complete analysis of 95% of the deaths during 48 hours of exposure of the worms to the extract showed effective larvicidal action. The antioxidant activity of the compound, in the face of the free radical sequestration method DPPH, presented an LD50 0.29 mg. mL-1. Regarding its toxicity, it showed a lethal concentration (LC50) of 35.7 ppm, indicating high toxicity, and remaining active for more than 48 hours.