Randomized controlled clinical trial of the antimicrobial efficacy of green propolis against bacteria prevalent in participants with chronic wounds, in the sertão of paraíba-ne

Propolis is used to treat a variety of ailments, including ulcer and wound healing. The phytochemical tracking of Brazilian propolis indicates the presence of flavonoids, biologically active ingredients. In the present study, we sought to evaluate the potential antimicrobial effect of Brazilian propolis on chronic wounds in humans, in an experimental study. This is a clinical trial of treatment, randomized, controlled, single-blind, used for 30 days, on an experimental basis in human beings, prospective 40 participants (20 intervention, treated with 5% green propolis ointment, 20 control, treated with AGE- essential fatty acid plus vitamins A and E). epithelialized, with a reduction to 4.8% of lesions with purulent exudate, 90.5% epithelialized the edges, and were clean-contaminated, 23.8% referred pain. In the control group, using AGE, 33.3% had epithelialization, 19% had purulent exudate, 57.1% epithelialized edges, 76.2% were clean-contaminated, 42.9% referred pain. Revealing the antimicrobial effects of Brazilian propolis, with the evolution of granulation tissue, reduction of necrotic tissue and formation of new epithelial tissue. The Brazilian green propolis, with topical application at 5%, promoted an expressive action in the tissue repair process. Thus, considering the relevance of its beneficial effects, propolis is a promising natural product for skin healing.