Relationship between plaque psoriasis and atherosclerosis in Iraqi patients

Background: To evaluate the state of some biochemical markers and lipid profilein sera of plaque psoriatic patients.
Aim: The aim of this study is to investigate the levels of inflammatory markers and lipid profile in plaque psoriatic and control groups, and their relationship with the plaque psoriasis.
Patients and Methods: The study was conducted on sixty patients with plaque psoriasis and thirty apparently healthy individuals were taken as control group.The sera obtained from the blood were used to determine the level of Leptin, TNF-alpha, IL-6 and hs-CRP concentrations in both groups by enzyme linked immunosorbant assay (ELISA) method. Determination of total serum cholesterol, LDL, VLDL, TG and HDL by enzymatically method. Also determine the correlation of the inflammatory markers with the plaque psoriasis.
Results and Discussion: The results of the present study showed a significant increase(P> 0.001) in leptin, TNF-alpha, IL-6,hs-CRP concentration and a significant decrease (P> 0.05) in HDL in sera of plaque psoriasis group compared with those of the control group.The results of linear regression analysis show a significant positive correlation of leptin, with TNF-alpha (r = 0.95, p< 0.001), and IL-6 (r = 0.98, p < 0.001) and CRP with TNF-alpha (r = 0.92, p< 0.001), and IL-6 (r = 0.96, p < 0.01)   in plaque Psoriasis.
Conclusion: There is relationship between plaque psoriasis and atherosclerosis and a good significant correlation between leptin and lL-6.