Structure based drug design for ndm1 inhibitors identification of antibacterial resistance

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Author: 
Thiyagarajan, C. and Thirumalaivasan, P.
Abstract: 

The β-lactam antibiotics have long been a cornerstone for the treatment of bacterial infection. Recently, a readily transferable antibiotic resistance factor called the New Delhi metallo-Beta-lactamase-1 (NDM-1) has been found to confer enteric bacteria resistance to nearly all β-lactams antibiotics, including the heralded carbapenems, posing a serious threat to human health. In study to identify suitable NDM-1 inhibitors from Chembridge database using Virtual screening and molecular docking approach. Finally, this study provides a platform for the development of a novel potential inhibitor of NDM-1, which may be considered as a potential drug candidate against bacterial resistance.

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