Study of enones as novel aldose reductase inhibitors
International Journal of Development Research
Study of enones as novel aldose reductase inhibitors
Received 22nd February, 2017; Received in revised form 22nd March, 2017; Accepted 27th April, 2017; Published online 18th May, 2017
Copyright©2017, Mule et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aldose reductase is an NADPH-dependent oxidoreductase that catalyzes the reduction of glucose to sorbitol, the first step in Aldose polyol pathway and this enzyme has been implicated in the development of late diabetic complications . As a consequence, inhibition of this enzyme has gained therapeutic significance and has been the drug target. Conjugated enone moiety present in natural product curcumin shows excellent inhibitory activity for aldose reductase and along these lines we have synthesised a series of conjucated enones and tested their activity. As expected the synthesised enones bearing difffernt functional groups on the aromatic ring display good to exclent activity.
