Study of microcrystalline cellulose as a substitute of magnesium stearate towards functionality of lubricant in aspirin formulation

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International Journal of Development Research

Volume: 
7
Article ID: 
10374
6 pages
Research Article

Study of microcrystalline cellulose as a substitute of magnesium stearate towards functionality of lubricant in aspirin formulation

Jilika Shah, Monika Tomar, Ajay Kumar Singh and Amit Raj Sinha

Abstract: 

In pharmaceutical industries, magnesium stearate is used as a lubricating agent. It is frequently used in the solid dosage forms. In solid dosage forms generally it is used in the concentration of 0.2 % to 2.0%. However, it decreases hardness of tablet in some formulations. Microcrystalline cellulose is very good excipient, it has excellent binding property. In solid dosage forms, it works as a good lubricant, disintegrant, binder and filler. Concentration of lubricants in formulation should be balanced in terms of the adverse effects of used lubricant. In this study we have manufactured aspirin tablets by direct compression with different concentration (0.05% to 2.00%) of magnesium stearate and microcrystalline cellulose and then evaluated pre compression and post compression study. In pre compression study, we have evaluated bulk density, tapped density, angle of repose of aspirin tablet blend and in the post compression study, we have evaluated weight uniformity, hardness, percentage friability, disintegration time and dissolution profile of aspirin tablet.

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