The value of 18f-fluorodeoxyglucose and MRI DWI in underpinning cellular reprogramming in breast cancer

International Journal of Development Research

Article ID: 
5 pages
Research Article

The value of 18f-fluorodeoxyglucose and MRI DWI in underpinning cellular reprogramming in breast cancer

Shazreen, S., Sohel, R., Shakher, R., Cheah, Y.Q., Malini, V.K., Shahrun Niza, A.S., Saladina, J.J. and Fathinul Fikri, A.S.


Background: The value of Apparent diffusion coefficient (ADC) derived from the MRI-DWI in differentiating benign from malignant breast cancer is scarce. The known FDG-avid breast cancer is well known and the potential of correlating the ADC and the degree of altered glucose metabolism evaluated by SUV max (FDG PET) is largely unknown. Objective: The aim of this study is to determine correlations between SUV max (18 F-FDG PET/CT) and ADC value (MRI DWI) in patients with primary breast carcinoma. Subjects and Methods: There were 13 consecutive breast cancer patients with BIRADS 4 or 5 were recruited from an endocrinology clinic. All patients underwent 18F-FDG PET/CT and MRI DWI. For the purpose of interpretation, results were analyzed according to the standardized uptake value (SUV max) whereby a lesion with is higher inherent metabolic activity than the mediastinal blood pool on FDG-PET/CT determined a positive finding Multiparametric MRI of the breast utilizing MRI DWI was performed on all patients with b values, 50 and 900 s/mm2. Apparent Diffusion Coefficient (ADC) values were generated automatically through soft-ware system. Data were analyzed using the Kendell Tau correlation, ANOVA and independent t test. All statistical tests with P values <0.05 were considered statistically significant. Results: There were 13 female with mean age of 57±9.7 years with proven biopsy of malignant lesion (5;38.5%) and benign (8;61.5%). There was a significant different between mean SUVmax of primary malignant (5.36±2.24 g/dl) and benign was (1.85±0.33g/dl) ; p<0.05). On the lesion MRI-DWI, there was significant association between the high signal change of benign lesion versus malignancy with p<0.05. There was also significant difference between the ADCmin for malignant is (0.84±0.25×10−3 mm2/s) versus benign (1.53±0.19 mm), p < 0.05. A significant inverse Kendall tau’ correlation coefficient was found between SUV max and ADC min (r ;-0.46, p=0.03). Conclusion and future works: The utility of SUV max and ADC value in differentiating benign from malignant breast lesions are potentially powerful as a surrogate markers for early detection and therapeutic response for early recognition of high risk patient in developing breast cancer.

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