Objective: To evaluate in vitro, the synergistic effects of bioactive extracts of Punica granatum (Pomegranate) "pulp", Actinidia deliciosa (Kiwifruit) "peel" and Citrus maxima (Pomelo) "pulp" with different antibiotics against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Methods: The extraction was carried out using the soxhlet in presence of ethanol, methanol or water. Evaluation of synergistic activity was carried out using disc diffusion method. Results: The results pointed that some of crude extracts showed a synergistic activity against the tested bacteria, and some extract showed no synergistic effect. The highest synergistic effect was observed with streptomycin and ciprofloxancin. Conclusion: Obviously the wide use of antibiotics in the treatment of bacterial infections has led to spread of resistant strains so we need to find a source of bioactive substances that could possess broad spectrum of activity when it is combined with antibiotic to be able resist the pathogenic microorganism.
Prof. Dr. Bilal BİLGİN