Adiposity, metabolic parameters and c-reactive protein in patients at cardiovascular risk

Background: Several studies have shown that C-reactive protein is positively associated with the body mass index (BMI) and waist circumference (WC), but the association of the concentration of C reactive protein with lipid and glycemic profile is still controversial. This study aimed to determine high-sensitive C-reactive protein (hs-CRP) concentrations in patients undergoing angiography and its correlation with BMI, WC and biochemical parameters. Ninety-seven patients attended the Unit of Cardiac Surgery and Hemodynamics located at University Hospital of the University of Marília (UNIMAR) participated in the study. Anthropometric (weight and height for calculation of BMI and WC) and biochemical parameters (hs-CRP, glycaemia, total cholesterol, LDL-c, HDL-c, and triglycerides) were collected. Pearson test was used to evaluate the correlation between the data and the significance level adopted was 5% ( p <0.05). The patients had a mean age of 55 ± 12.04 years, and 55.32% were men and 44.68% women. The mean values of hs-CRP were 0.40 ± 0.42 mg/dL. hs-CRP correlated positively with BMI (p < 0.008) and WC (p < 0.018) but not with other variables such as blood glucose ( p = 0.118), total cholesterol (p = 0.559), LDL-c (p = 0.8180, HDL-c (p = 0.417) and triglycerides (p = 0.590). Body composition, characterized by increased body adiposity according to BMI and WC were the main factors related to high concentrations of hs-CRP in the patients underwent coronary arteriography.