Estrogen route reposition does not affect postprandial lipemia and inflammation in patients with turner syndrome

Aims: The aim of the present study was to examine the influence of estrogen route reposition on the response of postprandial lipemia and its impact on leukocyte and platelets recruitment, subclinical inflammation and carotid intima-media thickness in patients with Turner syndrome. Method: A cross-sectional study was conducted to evaluate the correlation between postprandial lipemia and fasting glycemia, insulin, carotid intima-media thickness, white blood cells and platelets count in 25 Turner syndrome patients. All patients were using oral progesterone, 11 on oral estrogen and 14 on transdermal estrogen. Results: The age, carotid intima-media thickness, fasting glucose, insulin and lipid profiles were similar between groups. We did not observe any difference between the oral and transdermal hormone replace therapy with regard to the amount of postprandial triglycerides, the delta value of total white blood cells and neutrophils. The platelets increased significantly only in the oral group of estrogen reposition and there was no difference in the platelets increase between subgroups. There is no correlation between the delta value of triglycerides and the delta values of CRP, platelets, total leukocytes and differential counts or the absolute value of carotid intima-media thickness. Conclusion: We conclude that the route of estrogen reposition does not affect the extent of postprandial lipemia and its consequences for leukocyte, platelet recruitment and carotid intima-media thickness.