Multicomponent synthesis and antimicrobial activity of series of pyranopyrazoles analogous employed by natural lemon juice

In present study most significance synthesis of pyranopyrazoles derivatives, numerous methods procedure for their synthesis was developed. The number of drawbacks was suffered from the previous method of procedure for preparation of derivatives pyranopyrazoles including difficulty to the workup; longer time reaction, expensive cost of reagents and organic solvents effects. The present research article reported and these were synthesis of titled derivatives can be obtained from the mixture Ethyl acetoacetate (1mol), hydrazine hydrate (1mol), substituted aromatic aldehyde (1mol), malononitrile (1mol) and catalyst i.e., natural Lemon Juice (20mmol g). The newly derivatives determined by the 1HNMR spectra,13CNMR spectra and LCMS spectra, polarity and antimicrobial activity were also studied. The reaction was performed without the use of organic solvents. The components used in the mixture were easily available. The reaction required only less time and reactions were done at RT.