Rp-Hplc Method Development & Validation for Carvedilol, Ivabradine Hydrochloride Drug in Bulk & it’s Pharmaceutical Dosage form

A simple, sensitive, accurate, cost-effective, and stability-indicating HPLC method was developed and validated for the simultaneous estimation of Carvediloland Ivabradine hydrochloride in bulk drugs and combined dosage forms. The method used a Symmetry VL-G4288C UV detector (5 μm) at 265 nm with a 20 μL injection. Carvedilol and Ivabradine hydrochloride showed retention times of 6.973 and 3.876 minutes. It was linear from 1 μg/mL to 12.5 mg/mL for Carvedilol and from 5 mg/mL for Ivabradine, with a detection limit of 0.1 μg/mL for both. Validation confirmed accuracy, precision, and stability, with samples stable for 40 hours and standards for 42 hours.