Oral supplementation with campomanesia adamantium peel extract: effect on metabolic and inflammatory profiles in mice

Campomanesia adamantium (“guavira”) fruits exhibit pronounced antioxidant activity and are popularly used in the control of metabolic comorbidities, but no studies have evaluated this antioxidantproperty in the fruit peel.We evaluatedthe effect of the hydroethanolic extract ofC. adamantium peel (ExCa) on the metabolic and inflammatory profilesof mice. Antioxidant activity was evaluatedin vitro.The animals, fed a diet containing 65% starch, were grouped (n=8 each group) as follows: ExCa 250 (extract supplementation, 250mg/kg), ExCa500 (500mg/kg), and control (water supplementation). The experiment lasted 16 weeks.Supplementation was given by gavagefor the final four weeks. Body weight and dietary intake were measured. Blood was evaluated forinsulin, C-reactive protein, glucose, urea, creatinine, triglycerides, and inflammatory cytokines. Liver and kidneys were histologically examined. ExCaexhibited antioxidant potential, with high levels of phenolic compounds and tannins. Only supplementation with ExCaat 500 mg/kg reduced body weight, levels of glucose, triglycerides, total cholesterol, and hepatic steatosis, but thisregimen promotedkidney and liver inflammation.Inflammatory cytokines were not affected by extract. Supplementation withExCa showed potential utility as a nutritional strategy for the treatment of metabolic syndromecomorbidities.