Superior Formulation Strategy and Advanced Characterisation of Liposomal Magnesium: a Novel Approach by Wbcil

Liposomal Magnesium (Magnesium) is known to achieve a higher absorption rate to human body, approximatelytriple to that of non-liposomal forms, by enhancing cellular delivery of magnesium through lymphatic transport system; thereby improving gastrointestinal tolerance. The stability of Liposomal Magnesiumformulated by West Bengal Chemical Industries Ltd., Kolkata, India (WBCIL) exhibits high stability, attributed to its phospholipid-rich bilayer structure composed of 82.05% phosphatidylcholine and 10.82% phosphatidylethanolamine. WBCIL has extensively characterised the formulation using a range of physicochemical and stability assessments. These include evaluations of encapsulation efficiency, particle size distribution, zeta potential, spectrometric and morphological analyses, elemental composition, leakage behaviour, and thermal stability. The results suggest that Liposomal Magnesiumachieved a high encapsulation efficiency of 80.03%, with a small particle size of 212.3 nm, a polydispersity index (PDI) of 0.3454, and a zeta potential of –34.83 mV, indicating good dispersion stability. Fourier Transform Infrared (FTIR) spectroscopy confirmed the structural integrity and chemical interactions within the formulation, revealing characteristic C–H (hydrophobic) stretching peaks at 2918 cm⁻¹ and 2845 cm⁻¹, along with an O–H (hydrophilic) stretching peak at 3410 cm⁻¹. Elemental analysis showed the presence of only oxygen (25.85%), carbon (56.58%), nitrogen (17.33%), and phosphorus (0.24%), supporting the purity and consistency of the formulation. Scanning Electron Microscopy (SEM) analysis revealed a well-defined morphology with no signs of particle aggregation. Leakage studies further confirmed excellent stability of the formulation, showing minimal leakage over time. Additionally, thermal stability testing at 105°C for 4 hours demonstrated the strong structural resilience and sustained encapsulation capability of the liposome under stress conditions. Overall, the evaluated parameters indicate that the Liposomal Magnesium formulation developed by WBCIL possesses strong potential for consistent long-term storage without degradation and leakage even under high-temperature conditions.