Vancomycin and cephalosporin use as a first choice of antimicrobial therapy in neonatal intensive care unit: impact on a late-onset sepsis
International Journal of Development Research
Vancomycin and cephalosporin use as a first choice of antimicrobial therapy in neonatal intensive care unit: impact on a late-onset sepsis
Received 03rd June, 2019; Received in revised form 07th July, 2019; Accepted 14th August, 2019; Published online 28th September, 2019
Copyright © 2019, Ralciane de Paula Menezes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: late-onset sepsis continues to be an important cause of morbidity and mortality and appropriate antibiotic treatment is one of the cornerstones of successful treatment. The aims of this study were: to evaluate the rate of late onset sepsis, risk factors for disease and pathogenic micro-organisms isolated in one neonatal intensive care unit were compared following a change in antibiotic policy. Methods: the comparison was performed between three time periods: A (Sept 2010 to Aug 2011), B (Dec 2011 to Nov 2012), C (May 2013 to Apr 2014). The periods were based on different antibiotic protocols during each one. Results: we analysed 632 newborns, the use PICC was 70%, and 64.5% were associated with sepsis. The infection rate was 34.5%, and sepsis was the infection with higher frequency and the occurrence of death was 11.9%. There was no statistically significant difference in the reduction of Gram-positive organisms. Conclusion: After two changes in the protocol of use for antibiotics, we concluded that there was no impact on the frequency of sepsis in changing empiric antibiotic therapy for LOS. The results highlight the importance of using antibiotics judiciously in NICU settings, which may minimize the collateral damage associated with antibiotic therapy and benefit neonatal outcomes.
