Vitamin d and inflammatory markers in obese women

Introduction: Currently, some nutrients have been the target of science due to the relationship they can establish with many chronic diseases, especially obesity. Vitamin D, with prominence, has received great attention for its role in maintaining glucose homeostasis and in regulating the inflammatory pathways characteristic of obese individuals. Objective: This study aimed to associate vitamin D concentrations with inflammatory markers in obese women. Methods: Case-control study involving 76 women (20 to 50 years old), categorized according to the BMI and with similar demographic and socioeconomic characteristics. For the analysis of vitamin D, high performance liquid chromatography (HPLC) associated with mass spectrophotometry was used.For serum levels of TNF-α, IL-1β, IL-6 and IL-10, blood serum was used, adopting the flow cytometry technique using a commercial human kit BD ™ Cytometric Bead Array (CBA) Human. Pearson and Chi-square tests were applied and the degree of association was tested using Cramer's coefficient. The p value <0.05 was adopted, and a 95% confidence interval. The project was approved by the Ethics Committee of the Federal University of Piaui (number1872442). Results: Vitamin D concentrations showed that 52.6% and 31.6% of obese women had deficiency and insufficiency, in that order. Obese women had high concentrations of TNF-α (p=0.04). Conclusion: There was an association between significantly reduced concentrations of vitamin D and high serum levels of TNF-α in the sample.