Nimbidin–induced downregulation of TNF-α mRNA in human monocytes infected with Mycobacterium tuberculosis
Tuberculosis (TB) is spiraling out of control at an alarming rate where reports implicate TNF-α to proliferate MTB 85B in infected host during early stage of infection. Reactive oxygen species plays an important role augmenting TNF-α, which in turn proliferates MTB 85B in bacilli-infected monocytes. Thus, in view of the above, an attempt was made to probe the antioxidant, anti-inflammatory and antimicrobial effects of phytochemicals from plants having medicinal value in combating TB.