Immunological response and zika mutations as a mechanism of microcephaly: systematic review and meta-analysis
Several circumstances may involve the development of microcephaly in the context of Zika infection. Mutations and the immune response caused by the virus may be part of the theoretical direction in the context. The aim of this study was to analyze the relationship between immune response or zika mutation and the development of microcephaly. A systematic review was conducted with meta-analysis on immunology and zika mutations in the development of microcephaly. A literature search was conducted on PubMed e Scopus online databases, with a search period for the past 5 years.