Safety assessment of doxycycline after an oral long-term administration in rats
Doxycycline has been widely studied for off-label use as neuroprotective and is capable to reduce oxidative stress in several neurodegenerative diseases. However, it is necessary to assess the safety of long-term exposure to doxycycline once neurodegenerative diseases generally require chronic treatments. Thus, we evaluated the safety of doxycycline in chronic use through hematological, biochemical, redox, and histological analysis. Male Wistar rats were divided into two groups: control (saline 0.9%) and experimental (10 mg/kg doxycycline/day), for 93 days, n=8 animals/group.