In-situ gel for nasal drug delivery
Oral drug delivery is the most desirable, preferred and convenient route for the administration of a drug, whenever systemic effects are intended, However, low oral bioavailability of some actives due to extensive hepatic metabolism and gastrointestinal degradation has prompted the search for more effective routes for their systemic delivery. Transmucosal routes of drug delivery (the mucosal linings of the nasal, rectal, vaginal and buccal cavity), parenteral route and transdermal route offer distinct advantages over peroral administration.