A novel antianxiety- like activity of amino guanidine in stressed mice: evidence of regulation by no: CGMP modulation
An investigation on possible regulation of antianxiety- like activity of amino guanidine in stressed mice by nitric oxide: cyclic guanosine monophosphate (NO: cGMP) modulation was made. Stressed mice were administered with amino guanidine and tested on elevated plus maze and light/dark box. NO: cGMP modulators (L-arginine, Methylene blue, Bay-607550, 8-Br-cGMP) were administered as pre-treatments in the separate groups of amino guanidine- treated stressed mice and modulation of the noted effect of amino guanidine in stressed mice was observed.