Past Issue

Gene editing by crispr/cas9 for treatment of huntington disease

Huntington's disease (HD) is an autosomal dominant full-penetrating neurodegenerative disorder and mutant gene is located in the short arm of chromosome 4, which encodes huntingtin protein and leads to degeneration of the basal ganglia in the brain, causing motor disorders and eventually communication. Patient`s DNA whit HD shows different number of cytosine-adenine-guanine trinucleotide (CAG) repeats, which indicates whether or not the person has the genetic defect of the disease.

Giant basal cell carcinoma: case reports

Background: Basal cell carcinoma is the most common malignant tumor and has an increased incidence in recent decades. The giant size is defined as a lesion larger than 5 cm in the largest diameter that commonly occurs in the trunk. Currently, decreasing in locations that have specialized services that are easier for the population to access. Case 1: A 54-year-old man, painter, showed an exulcerated plaque, with a friable surface and hypertrophic infiltrated margins of 12 cm in the largest diameter, located in the chest for 5 years.

Postharvest storage of Italian tomatoes using bacillus subtilisand salicylic acid

Tomato (Solanum lycoperscium) is one of the main vegetable crops and commonly grown around the world. The growing concern with food and environmental issues, as well as the rise of technologies with less environmental impact, makes it necessary to use bio-safe technological alternatives. Therefore, the objective of this study was to evaluate the application of Bacillus subtilis and Salicylic Acid in tomato post-harvest and their influence on the physical-chemical parameters of tomato fruits under cold storage.

Evaluation of pain in patients submitted acupuncture therapy in

Pain is characterized as an unpleasant, subjective sensation associated with an injury real or potential. Its involvement in physiological, cognitive and behavioral variables is recognized, considering the determinant complaints of people who seek treatment in health services. One of the means appreciated in the therapeutic environment to reduce painful symptoms is the use of the acupuncture technique, a process that takes place by redirecting and realigning energy, through the stimulation of specific points.

Availability and extent of utilization of financial resources in public secondary schools in Ebonyi State of Nigeria

Financial resources are described as materials of monetary value which can be expended on expenditure items. Individuals and organizations such as public secondary schools need financial resources to carry out operation in order to achieve objectives. Availability of financial resources to public secondary schools in Ebonyi State refers to both the percentage of government expenditure allocated to the sector and the ones raised from other sources by principals. These financial resources ought to be effectively utilized to achieve goals.

Comparing the efficacy of bevacizumab and ranibizumab in patients with retinal vein occlusion

The authors are commenting on the study entitled :“Comparing the efficacy of bevacizumab and ranibizumab in patients with retinal vein occlusion” published by Vader et al. in Ophthalmology Retina 2020;4(6):576-587,which compared the efficacy of intravitreal injections of bevacizumab to ranibizumab in the treatment of retinal vein occlusion– emergent macular edema. The study found that best-corrected visual acuity gain, anatomic outcomes, and safety were remarkably equivalent at 6 months in both treatment arms.

A rare presnetation of uti purple colour bag syndrome

It is a rare condition by intense purple discoloration of urine bag. Although typically 'benign'. Purple urine is not only alarming to patient , but can signal the presence of a UTI that needs a prompt treatment. The interaction between bag(plastic) and pigments and high bacterial load is important in precipitating the PUBS. Several bacteria mostly gram negative, which have been associated with PUBS are Providential Stuartii, providentiarettegri, klebsiellapneumoniae, Proteus mirabilis, E.Coli.

Repercussões do homicídio de trânsito na vida do suposto causador do acidente na cidade de teresina - pi

This study aimed to know traffic homicide repercussions in the life of the supposed causer of the accident. The research is qualitative, with ten drivers responding to criminal proceedings for negligence causing death in traffic. The thematic categories were: traffic accident history; feelings experienced during and after the accident; behavioral changes after the accident; legal repercussions after the traffic accident. The history of traffic accident was reported as a description of how it happened, with the exemption of the author´s responsibility for the fact.

24-Hour urinary sodium excretion in chronic kidney disease

Objective: To correlate urinary sodium excretion in isolated sample with 24-hour urine and glomerular filtration rate in patients with chronic kidney disease. Material and Methods: Cross-sectional study with 185 patients. Urinary sodium excretion was evaluated in 24-hour urine and in isolated sample. The statistics used the Student or Mann Whitney t tests and Pearson or Spearman’s correlation coefficients. Results: 58.9% were women, mean age of 59.8±12.1 years.

As Interferências na Sexualidade da Mulher Mastectomizada

A mastectomia é um procedimento cirúrgico que pode acarretar diversos agravos na vida da mulher diagnosticada com câncer de mama. Dentre estes, pode-se destacar os que acometem o seu psiquismo e consequentemente sua qualidade de vida, ressaltando as dificuldades associadas à satisfação sexual. A pesquisa é classificada como descritiva, de caráter exploratório com abordagem qualitativa. O estudo foi realizado com oito mulheres que passaram pela cirurgia de mastectomia. Como técnica para a exploração dos dados empíricos coletados, foi utilizada a análise de conteúdo de Bardin.