Past Issue

Effeicacy and safety of mytoxantrone associated with flag scheme in patients with relapsed or refractory acute leukemia

Objective: The objective of this investigation was determinate the complete remission, overall survival, disease-free survival and toxicity rates in patients with relapsed or refractory acute leukemia who received FLAG plus mitoxantrone (FLAG-MITO) chemotherapy. Patients and Methods: Prospective, experimental, longitudinal, unicentric, single-arm study. Oral fludarabine 30 mg/m2BSA, cytarabine 2000 mg/m2BSA, mitoxantrone 8 mg/m2BSA and granulocyte colony-stimulating factor 300 mg every 12 hours were administrated to patients with relapsed or refractory acute leukemia.

Influence of insect pest control and tillage practice in corn varieties on the occurrence of asiatic corn borer

A field experiment was conducted to evaluate the influence of pest control and tillage practice in hybrid and open-pollinated corn varieties at different growth stages on the occurrence of Asiatic corn borer (ACB) (OstriniafurnacalisGuenee) Pyralidaeand to assess its damage; and to determine the influence of pest control, tillage practice and varieties onpredator population.The experiment was laid out in Split-split plot in Randomized Complete Block Design (RCBD) with three replications.

Role of repetitive facilitation exercises in functional improvement of upper limb in stroke patients as compare to conventional rehabilitation

OBJECTIVE: To find the role of Repetitive facilitative exercises in functional improvement of upper limb in stroke patients as compare to conventional rehabilitation. METHODOLOGY: 26 patients fulfilling the inclusion and exclusion criteria were enrolled in this study. Outcome or efficacy was measured by using University of California-Los Angeles (UCLA) scoring system, a 35 point scale. The items measured included Pain (10 points), Function (10 points), Active forward flexion (5 points), strength of forward flexion (5 points) and patient satisfaction (5 points).

An endoscopic study for portal hypertensive colopathy and lower gastrointestinal bleeding in cirrhotic egyptian patients with history of hematemesis

Background: Liver cirrhosis is one of the most common health problems. It complicated by gastro esophageal varices, portal hypertension, portal hypertensive gastropathy and colopathy. However, the incidence and association of hypertensive colopathy with other complications of liver cirrhosis was not well addressed. Aim of the work: to endoscopic ally address portal hypertensive colopathy and other cirrhotic complications in cirrhotic Egyptian patients with or without hematemesis. Methodology: This study was carried out on sixty cirrhotic patients with portal hypertension.

Synthesis, characterization and pharmacological activity study of benzimidazole derivatives

Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and privileged structure in medicinal chemistry. It plays a very important role with plenty of useful therapeutic activities such as: antiulcers, antihypertensives, analgesic, anti-inflammatory, anti-virals, antifungals, anticancers, and antihistaminics.

The expression of cox- 2 and tgf β in oral submucous fibrosis

Oral submucous fibrosis (OSMF) is a chronic disease affecting the oral cavity and is associated with inflammation and fibrosis. The major aetiological factor is arecanut. Pro-inflammatory and pro-fibrotic cytokines such as cyclooxygenase-2 (COX-2) and transforming growth factor beta (TGF-β) respectively are stimulated by the alkaloids present in arecanut and probably have a major role in the pathogenesis of OSMF. The present study was aimed to evaluate their presence in different clinical stages and histopathologic grades of OSMF.

Endoscopic ultrasound adequacy rates using novel needle biopsy system with and without rapid onsite evaluation of various gastrointestinal and intra-abdominal solid lesions

Background and Aims: The Shark Core Fine Needle Biopsy (FNB) System is a tissue sampling device that can provide cytology and possibly higher yield histology samples. This needle system is being evaluated for adequacy in sampling of liver, pancreatic or gastric masses, and intra-abdominal lymphadenopathy visualized on prior imaging in addition to use of rapid onsite evaluation (ROSE) for adequacy. Methods: This retrospective study evaluated FNB adequacy for diagnostic purposes in 33 adults during the first six months of use. Primary endpoint was to determine adequacy of the sample.

A randomised control trial of ondansetron and metoclopramide in the prevention of post operative nausea and vomiting in thyroidectomy patients

Backgrounds: Nausea, retching and vomiting are among the most common post operative complaints next to pain for patients undergoing all surgical procedures requiring sedation and anaesthesia-general, regional or local anaesthesia. The incidence of post operative nausea and vomiting has been reported to be 1 in 1000,[1,2]. John Snow in 1848 has given extensive descriptions on nausea and vomiting[3] .He observed that vomiting was more likely to occur if the patient had eaten recently.

Maternal health care and practices of hill korwa particularly vulnerable tribal groups women of Chhattisgarh

The paper investigates the maternal health care and practices among the Hill Korwa women of Chhattisgarh state with special reference to the Jashpur district. Hill Korwa is one of the five primitive tribal groups of Chhattisgarh. The paper lists about the antenatal care, place of delivery, postnatal care and traditional practices, causes which affect maternal health and nutritional status of Hill Korwa women.

Chemotherapeutic agents in head and neck malignancies

Recent advances in the management of patients with head and neck cancer point to an expanding role of chemotherapy, resulting in an increased involvement of the medical oncologist in the multidisciplinary care of these patients. A comprehensive review of the clinical trial data that have defined new standards of care and a detailed presentation of widely used chemotherapeutic regimens, including both cytotoxic and molecularly targeted agents, are presented.