The evaluation of cancer incidence susceptibility in the liver of type 1 and 2 diabetic rats
The relationship between diabetes and cancer development is not clear. But the risk to develop cancer is increased if the person is diabetic. In the present study we induced type 1 and type 2 diabetes in rats by streptozotocin and high fat diet, respectively. Many cell growth and apoptosis related antigens were studied including tumour suppressor antigen; P53, anti-apoptotic protein bcl-2, pro-apoptotic protein bax, cyp1a2 and cyp2e1 and caspase 3.