Low immunohistochemical expression of e-cadherin is associated with better survival in high-grade urothelial cancer
Introduction: Urothelial carcinoma (UC) is the most common type of bladder cancer (BC). Approximately 75% of all BCs are restricted to the mucosa. Ten to 30% of superficial tumors will progress to invasive disease with worse prognosis. The epithelial to mesenchymal transition (EMT) is associated with the acquisition of tumor invasiveness and aggressive phenotypes. E-cadherin (E-CA) and vimentin are two proteins related to the EMT phenomenon.