Macroscopic effect of lipoic acid in skin injury in the model of diabetes mellitus induced by alloxan in rats
Objective: Evaluate the macroscopic effect of lipoic acid on skin lesion in rats with alloxan-induced diabetes mellitus model. Material and Methods: For diabetes induction, Wistar albino rats received Alloxan at 50mg/kg. After 72 hours, the glycemia was verified to confirm diabetes; animals with values below 250mg/dl were discarded. After the diagnosis, surgical excision of a skin fragment was performed with a 7 mm punch.