Solubility and Bioavailability Enhancement of poorly Water Soluble Drug Lercanidipine
The aim of the study was to enhance the solubility and dissolution rate of poorly water soluble drug lercanidipine by solid dispersion technique. Solid dispersion of lercanidipine was prepared by solvent evaporation and kneading technique by using polymer PVP K30 in 1:1, 1:3, 1:5 drug: polymer ratio respectively. Drug excipient compatibility study indicates that there is no interaction between the excipient and the drug. Total six batches were prepared and subjected to evaluation parameters.